Arthritis, affects TMJ by causing inflammation of the joints,. It can affect the temporomandibular joint, which connects the jaw to the skull. Arthritis, a condition that causes inflammation of the joints, is often associated with aging. Untreated TMJ disorders, e. g. , jaw locks, and long-term jaw clicking with clenching habits can lead to a person developing arthritis prematurely because clenching or grinding your teeth can cause the TMJ disc to deteriorate over time, causing contact between bones.